DDC anticorps

N° du produit ABIN318954

Cet anticorps anti-DDC est un anticorps Lapin Polyclonal détectant DDC dans WB. Adapté pour Rat et Boeuf (Vache).

Aperçu rapide pour DDC anticorps (ABIN318954)

Antigène: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reactivité: Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDC est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DDC anticorps

Specificité: This antibody recognises DOPA decarboxylase (aromatic-L-amino acid decarboxylase, DDC).

Purification: Affinity Chromatography.

Immunogène: SDS denatured, recombinant bovine DOPA decarboxylase expressed E. coli and purified from inclusion bodies.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000. This antibody detects a band of approximately 55 kDa in rat adrenalmedulla.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES pH 7.5, 150 mM NaCl containing 0.09 % Sodium Azide as preservative and 0.01 % BSA, 50 % Glycerol as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DDC

Antigène: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Autre désignation: AADC / DDC

Sujet: DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.Synonyms: Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase

ID gène: 280762

NCBI Accession: NP_776332

UniProt: P27718

Pathways: Dopaminergic Neurogenesis